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However, it is equally notable that GLP-1 R expression is reportedly undetectable in retinal and choroidal vasculature, the RPE, or other ocular structures [37]
This dual actiondriving energy production while simultaneously shielding the machinery from exhaust damagemakes CoQ10 indispensable for cellular survival
Thus, specific targeting of IGF-1R signaling post development may prove to be the best approach to achieve the benefits of low growth signals on healthspan and aging, without the potential unwanted side effects of combined adult-onset GH/IGF-1 deficiency
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